Medicines have different effect on each person. The Different response of medications in every human may be due to environmental factors, such as age, lifestyle, interaction with other drugs, or genetic factors identified in the individual's DNA.
Long-term scientific studies have shown that both the efficacy and the side effects as a result of medication intake depend largely on genetic factors. More than half of the world population has one or more variations in the genes associated with the response to drugs.
The detection of these genetic variants is now possible thanks to pharmacokinetic analysis, which studies the effect of individual genetic differences in response and toxicity to drugs, according to the basic principles of pharmacology and genetics.
Most prescribed drugs undergo oxidative metabolism catalyzed by cytochrome P450 and the enzyme CYP2D6, CYP2C19, CYP2C9, CYP1A2 and CYP3A5, whose enzymatic activity is genetically determined.
Pharmacogenetic individualized treatment analyses and identifies any genetic variations in these enzymes.
Pharmacogenetic analysis is oriented towards: